Table 1.
Combination index (CI) values of CE + DTX with different combination molar ratio at 50% growth inhibition point on B16 and MCF-7 cells (n = 3).
| CE + DTX | Combination molar ratio | |||||
|---|---|---|---|---|---|---|
| 0.25 | 0.5 | 1 | 2 | 4 | ||
| B16 | CI at IC50 | 0.49 ± 0.17 | 0.31 ± 0.13 | 0.47 ± 0.14 | 0.95 ± 0.26 | 1.08 ± 0.17 |
| Interpretation | synergism | strong synergism | synergism | additive effect | additive effect | |
| MCF-7 | CI at IC50 | 0.62 ± 0.13 | 0.48 ± 0.11 | 0.79 ± 0.25 | 1.17 ± 0.18 | 1.03 ± 0.19 |
| Interpretation | moderate synergism | synergism | moderate synergism | moderate antagonism | additive effect | |
Note: CI > 1.3: antagonism; CI 1.1–1.3: moderate antagonism; CI 0.9–1.1: additive effect; CI 0.8–0.9: slight synergism; CI 0.6–0.8: moderate synergism; CI 0.4–0.6: synergism; CI 0.2–0.4: strong synergism.