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. 2014 Mar 17;15(3):4619–4634. doi: 10.3390/ijms15034619

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — The expression of Rxfp1 (A) and Rxfp2 (B) protein in the patellar tissue homogenate from ovariectomised rats treated with testosterone with and without FLU and FIN. A decrease in Rxfp1 protein expression was noted following testosterone treatment which was antagonized by FLU and FIN. The expression of Rxfp2 protein was reduced following testosterone treatment which was also antagonized by FLU and FIN. The antagonizing effect of FIN indicated that DHT and not testosterone mediates the inhibition of Rxfp1 and Rxfp2 protein expression (C) (Data were expressed as mean ± SEM, n = 6 per treatment group; T125: 125 μg testosterone; T250: 250 μg testosterone; FLU: 10 mg/kg flutamide; FIN: 20 mg/kg finasteride). ^† p < 0.05 as compared to control; * p < 0.05 as compared to testosterone only treatment for the respective group.