Table 1.

Effect of pretreatment with vehicle (saline) or ADMA administered i.g. in graded doses ranging from 0.1 up to 40 mg/kg i.g. on the plasma levels of ADMA in rats exposed to 3.5 h of ischemia/reperfusion. Mean ± S.E.M of 6 rats per each group. An asterisk indicates a significant (p < 0.05) increase as compared with vehicle-control. An asterisk and cross indicate a significant difference (p < 0.05) when compared with the vehicle and ADMA applied in doses 1 or 10 mg/kg.

Experimental group	Plasma ADMA concentration (μmol/L)
Vehicle	1.46 ± 0.22
ADMA (0.1 mg/kg i.g.)	1.83 ± 0.36
ADMA (1 mg/kg i.g.)	2.37 ± 0.46 *
ADMA (10 mg/kg i.g.)	2.65 ± 0.34 *
ADMA (20 mg/kg i.g.)	3.62 ± 0.43 *+
ADMA (40 mg/kg i.g.)	4.95 ± 0.58 *+