Table 1.
Plasma pharmacokinetic parameters of fluralaner in dogs after either single oral or single i.v. administration
| Parameters | Oral 12.5 mg/kg n = 6 | Oral 25.0 mg/kg n = 6 | Oral 50.0 mg/kg n = 6 | Intravenous 12.5 mg/kg n = 6 |
|---|---|---|---|---|
| Cmax (ng/mL) |
2144 ± 860 |
3948 ± 1734 |
5419 ± 2086 |
7109 ± 908 |
| tmaxa (day) |
1 (range 0.08–2) |
1 (range 1–2) |
1 (range 0.17–3) |
n/a |
| AUC(0-d112) (day* ng/mL) |
29665 ± 13858 |
46115 ± 18932 |
70171 ± 26412 |
87198 ± 11835 |
| AUC(0→∞) (day*ng/mL) |
29922 ± 13808 |
46416 ± 18929 |
70531 ± 26529 |
87779 ± 12004 |
| t1/2 (day) |
13 ± 1 |
12 ± 3 |
14 ± 1 |
15 ± 2 |
| MRT (day) |
19 ± 2 |
15 ± 4 |
17 ± 3 |
20 ± 3 |
| Cl (L/kg/day) |
n/a |
n/a |
n/a |
0.14 ± 0.02 |
| Vz (L/kg) | n/a | n/a | n/a | 3.1 ± 0.5 |
aMedian, other values are mean ± standard deviation.
n/a - not applicable.