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. 2014 Apr 2;9:13. doi: 10.1186/1750-1326-9-13

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Copyright © 2014 Guzmán et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical staining pattern of Aβ_5-Xin cortex of sporadic AD human brain. Vascular Aβ_5-x immunoreactivity (A, E, F) was detected in the majority of the SAD cases analyzed in hippocampus (A) and cerebral cortex (E), whereas extracellular Aβ_5-x-positive deposits (C, G, H) were less abundant in both brain areas (C, D). The pan-Aβ antibody 24311 (B, D) demonstrates cerebral amyloid angiopathy (CAA) and plaque load (arrows). The same cortical region stained in a parallel section with the AB5-3 antibody (F, H) binds preferentially to blood vessels presenting CAA and barely recognizes plaques. Scale bar: 50 μm.