Table 2.
Determinants of Kaposi sarcoma–associated herpesvirus infection in children in South Africa and Uganda.
| South Africa |
Uganda |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Unadjusted OR (95% CI) | P | Adjusted OR (95% CI)a | P | Unadjusted OR (95% CI) | P | Adjusted OR (95% CI)a | P | P for interactionb |
| Age, per 1 year increase | 0.98 (0.85−1.1) | .80 | 0.96 (0.81−1.1) | .64 | 1.3 (1.2−1.4) | <.001 | 1.3 (1.2−1.4) | <.001 | <.001 |
| Sex | |||||||||
| Female | Reference | Reference | Reference | Reference | |||||
| Male | 0.45 (0.18−1.1) | .09 | 0.44 (0.18−1.1) | .08 | 0.90 (0.58−1.4) | .62 | 0.96 (0.66−1.4) | .82 | .14 |
| HIV infection status | |||||||||
| Uninfected | Reference | Reference | Reference | Reference | |||||
| Infected | 2.2 (0.72−6.8) | .17 | 0.93 (0.12−7.5) | .95 | 0.17 (0.04−0.70) | .01 | 0.22 (0.06−0.87) | .03 | .22 |
| Study Site | |||||||||
| South Africa | |||||||||
| Rural | Reference | Reference | ... | ... | |||||
| Urban | 1.7 (0.82−3.4) | .16 | 1.5 (0.63−3.5) | .36 | ... | ... | |||
| Uganda | |||||||||
| Clinic based | ... | ... | Reference | Reference | |||||
| Population based | ... | ... | 2.7 (1.9−3.9) | <.001 | 1.5 (0.94−2.4) | .09 | |||
NOTE. CI, confidence interval; OR, odds ratio.
a
Adjusted for all characteristics.
b
The P for interaction term indicates whether the magnitude of association between a specific characteristic and Kaposi sarcoma–associated herpesvirus seropositivity, after adjusting for all other characteristics, differed between the Ugandan and South African populations. A small P value is indicative of a difference between populations, and a large Pvalue is indicative of no evidence for a difference.