Table 2.
Potential Migraine Preventative Medications and Weight Considerations
| Drug Class/Drug | Weight Change |
|---|---|
| Antidepressants | |
| Amitriptyline | ↑↑↑ |
| Nortriptyline | ↑↑ |
| Protriptyline | ↓ |
| Venlafaxine | ↔↓ |
| Duloxetine | ↔↓ |
| Anticonvulsants | |
| Divalproex sodium | ↑↑↑ |
| Lamotrigine | ↔ |
| Gabapentin | ↑ |
| Topiramate | ↓↓ |
| β-Blockers | |
| Propranolol | ↑ |
| Timolol | ↔ |
| Metoprolol | ↑ |
| Angiotensin II receptor blocker | |
| Candesartan | ↔↓ |
| Telmisartan | ↓ |
| ACE-inhibitor | |
| Captopril | ↔↓ |
| Lisinopril | ↔ |
| Serotonin antagonists | |
| Methysergide | ↑↑↑ |
| Cyproheptadine | ↑↑↑ |
| Calcium channel blockers | |
| Flunarizine | ↑↑↑ |
| Verapamil | ↔ |
Modified based on Peterlin et al 2008.86
ACE-inhibitor = angiotensin-converting-enzyme inhibitor.