Table 2.

Replication of European asthma-associated SNPs in the CARe African-American meta-analyses

Locus	Reported SNP	References	EAF-CARe	CARe SNP	Ancestry specific r2	African ancestry r2	EAF	p value-one tailed	Effect direction
RAD50/IL13	rs2244012	Moffatt et al. (2010)	0.5943	rs17622991	0.86971	0.117662	0.195	1.07E–05	+
IL1RL1/IL18R1	rsl0173081	Moffatt et al. (2010)	0.7394	rs17027029	0.773331	0.511213	0.688	9.97E–05	+
GSDMB/ORMDL3	rs2305480	Moffatt et al. (2010)	0.8424	rs869402	0.79411	0.570927	0.801	1.25E–04	+
10pl4 (gene desert)	rs10508372	Hirota et al. (2011)	0.8016	rs11255975	0.985498	0.793969	0.777	8.49E–04	+

Reported SNP refers to the top SNP at the particular locus from the referenced GWA studies, and CARe SNP refers the top SNP in the CARe African-American cohort. EAF-CARe is the effect allele frequency for the reported SNP in CARe. EAF is the effect allele frequency for the “better” SNP (i.e., the SNP with the strongest signal of replication) in CARe. Effect direction: + indicates that the CARe SNP effect was in the same direction as the reported SNP