Table 4.

Joint analysis of Hopkins/Emory cases for significant independent predictors of decreased overall survival on multivariate analysis

	p-value	Hazard ratio (95% C.I.)
Overall survival (n=549)
Tumoral ATM loss without abnormal TP53	p=0.009	2.61 (1.27–5.37)
Poor Differentiation (WD/MD vs. PD)	p<0.001	1.81 (0.99–3.29)
Positive surgical resection margin	p<0.001	1.55 (1.23–1.94)
Lymph node metastasis	p<0.001	1.97 (1.41–2.76)
Age (≥65 years)	p=0.024	1.28 (1.03–1.59)
Treating institution	p=0.042	0.62 (0.40–0.98)
Treatment period	p=0.003	0.06 (0.01–0.44)

WD: well-differentiated, MD: moderately differentiated, PD: poorly differentiated