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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Dermatol Sci. 2014 Jan 18;74(2):106–115. doi: 10.1016/j.jdermsci.2014.01.002

Figure 3. Differential TSP-2 expression in normal skin, SCC and tumor stroma in wild-type and transgenic mice.

Figure 3

In situ hybridization confirmed moderately enhanced TSP-2 mRNA expression in the normal skin (B,D) of TSP-2 transgenic mice and a strong TSP-2 expression in the SCC of TSP-2 transgenic mice (F, H), whereas little or no TSP-2 mRNA was detectable in the normal skin (A, C) or the SCC of wild-type mice (E, G). Immunofluorescence stains for TSP-2 (green) demonstrate pronounced deposition of TSP-2 protein predominantly in the tumor stroma in TSP-2 transgenic SCC (J), as compared to weak TSP-2 protein expression in wild-type SCC (I). Bar = 100 µm. Western blot demonstrates high levels of TSP-2 expression in the skin and in tumors of TSP-2 transgenic mice in contrast to low protein levels in wild-type mice (K).