Table 1.
Patient Characteristics
| Characteristic | HCC patients (n=452) |
Non-HCC patients (n=676) |
p-value |
|---|---|---|---|
| Age (years) | 56 (52 – 61) | 55 (49- 61) | 0.01 |
| Gender (% male) | 355 (78.4%) | 447 (66.2%) | < 0.001 |
| Race Caucasian Black Hispanic Other |
119 (26.4%) 160 (35.5%) 134 (29.7%) 38 (8.4%) |
231 (34.2%) 147 (21.8%) 278 (41.2%) 19 (2.8%) |
< 0.001 |
| BMI | 25.4 (22 – 29) | 28.7 (25 – 33) | < 0.001 |
| Etiology of Liver Disease Hepatitis C Hepatitis B Alcohol induced NASH Other |
314 (69.5%) 41 (9.1%) 56 (12.4%) 39 (8.6%) 2 (0.4%) |
362 (53.5%) 23 (3.4%) 192 (28.4%) 77 (11.4%) 22 (3.3%) |
< 0.001 |
| Presence of ascites | 211 (46.7%) | 260 (38.5%) | 0.007 |
| Presence of hepatic encephalopathy |
71 (15.7%) | 145 (21.5%) | 0.02 |
| HIV positive status** | 29 (9.0%) | 51 (11.9%) | 0.23 |
| Platelet count (×103/μL) | 129 (82 – 203) | 97 (66 – 138) | <0.001 |
| Creatinine (mg/dL) | 0.8 (0.7 – 1.0) | 0.8 (0.7 – 1.1) | 0.85 |
| Albumin (g/dL) | 3.0 (2.6 – 3.5) | 3.5 (2.9 – 3.9) | <0.001 |
| AST (U/L) | 110 (64 – 180) | 58 (39 – 92) | <0.001 |
| ALT (U/L) | 54 (35 – 83) | 40 (26 – 67) | <0.001 |
| Bilirubin (mg/dL) | 1.4 (0.8 – 2.8) | 1.1 (0.6 – 1.9) | <0.001 |
| INR | 1.2 (1.1 – 1.5) | 1.2 (1.1 – 1.4) | <0.001 |
| AFP level (ng/mL) | 198 (13 – 4114) | 4 (3 – 8) | <0.001 |
| Child Pugh Class Child Pugh A Child Pugh B |
168 (37.2%) 189 (41.8%) |
197 (29.1%) 403 (59.6%) |
<0.001 |
| Early Tumor Stage* (%) | 150 (33%) |
All values are expressed as median (interquartile range) unless otherwise specified. Percentages for categorical variables were calculated after accounting for missing data.
*
Early tumor stage was defined using Milan Criteria
**
HIV serostatus was available in 67% (n=751) of patients
AFP – alpha fetoprotein; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – Body mass index; HCC – hepatocellular carcinoma; HIV – human immunodeficiency virus; INR – international normalized ratio; NASH – nonalcoholic steatohepatitis