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. 2014 Feb 6;21(4):353–362. doi: 10.1038/gt.2014.3

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Macrophage-specific expression of APN reduced atherosclerotic lesions in ApoE knockout mice. (a) Representative images of Sudan-stained atherosclerotic lesions after application of lentiviral vectors for 2 weeks. Lenti-SP-APN-infected arteries showed a significant reduction of lipid deposit compared with that in Lenti-GFP- and Lenti-APN-infected arteries. (b) Hematoxylin and eosin (H&E) staining and oil red O staining were performed to characterize the lesions in lentiviral vector-infected lesions. (c) Macrophages were observed in all the lesions (F4/80). The expression of APN was detected in Lenti-APN- and Lenti-SP-APN-infected lesions. The size of the lesion was reduced by Lenti-SP-APN infection. APN, adiponectin.