Figure 6. Effect of chronic losartan on central and peripheral indices of stress activation.

Plasma corticosterone levels (A) and plasma renin activity (B) in mice treated with vehicle or losartan for 2 weeks following acute restraint stress (n =9–10/group). Induction of c-Fos protein quantified as number of positive cell counts per section of paraventricular nucleus (C) (n = 5–7/group). Representative images showing reduced cFos protein induction in losartan versus vehicle animals exposed to acute restraint stress (D–E). *P < 0.05