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. 2014 Mar 3;11:39. doi: 10.1186/1742-2094-11-39

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Copyright © 2014 Niesman et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Electrophysiological properties of the commissural-collateral input in the CA1 region of the hippocampus at 1 week post-traumatic brain injury (TBI). (A) Representative responses in slices from the contralateral (Contra; left) and the TBI (controlled cortical impact (CCI), right) hippocampus before and after the tetanus. (B) Long-term potentiation (LTP) of monosynaptic responses after CCI. (C) Changes of polysynaptic response (averaged amplitude at latencies 12 to 45 ms after the stimulus). (D) Enhanced NADPH oxidase (Nox) activity in both ipsilateral and contralateral hemispheres 24 hours and 1 week post-TBI as shown by increased superoxide electron paramagnetic resonance (EPR) signal amplitude relative to sham animals. (E) Isolated synaptosomes from the ipsilateral side exhibited greater Nox activity, which increased 1 week post-CCI. Con, control; Contra, contralateral; fEPSP, field excitatory postsynaptic potential; Ispi, ipsilateral.