Table 1.
Clinicopathological features and EGFR gene status of the 44 adrenocortical tumors
| Malignant (n = 22) | Benign (n = 22) | p value | |
|---|---|---|---|
| Age (yrs) | |||
| Mean |
43.4 |
47.4 |
0.364 |
| Range |
2–75 |
34–69 |
|
| Sex | |||
| Males |
13 |
9 |
0.228 |
| Females |
9 |
13 |
|
| Hormonal function | |||
| Functioning |
8 |
7 |
0.498 |
| Non-functioning |
14 |
15 |
|
| Tumor location | |||
| Right |
14 |
13 |
0.757 |
| Left |
8 |
9 |
|
| Tumor size (cm) | |||
| Mean |
12.3 |
2.9 |
<0.001* |
| Range |
3-24 |
0.8-5.5 |
|
| Tumor weight (g) | |||
| Mean |
847.0 |
10.6 |
<0.001* |
| Range |
12-3250 |
1-42 |
|
| EGFR copy number | |||
| Positive |
11 |
0 |
<0.001*,† |
| Negative |
11 |
22 |
|
| EGFR IHC | |||
| Positive |
14 |
7 |
0.035* |
| Negative | 8 | 15 | |
EGFR, epidermal growth factor receptor; IHC, immunohistochemistry.
*Statistically significant.
†Fisher’s exact test (two-tailed).