Figure 5. Effect of tissue co-engraftment on mitotic/apoptotic indices of tumor cells.

( a) Higher magnification fluorescence micrographs showing LLC tumor cells growing in indicated tissues (9 days post-implantation) to assess their effect on relative tumor cell mitosis and apoptosis. Mitotic (arrows) and apoptotic (arrowheads) cells were counted to determine the ratio of mitotic cells to apoptotic cells ( b). Scale bar = 100 μm. Mean +/- SD are shown. * = p<0.05. n = 3–4 mice for all experiments.