Figure 2.
Neonatal oxygen exposure increases AHR to methacholine in adult mice. Airway resistance and lung compliance were evaluated in adult female and male mice exposed as neonates to room air (Air Ctl) or 100% oxygen (O2 Ctl ). Values represent the geometric mean + SE for 7-9 animals administered increasing amounts of methacholine intravenously (0.03 – 3.0 μg/kg). * p<0.05 by repeated measures ANOVA.