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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Pediatr Allergy Immunol. 2014 Feb 13;25(2):180–186. doi: 10.1111/pai.12206

Figure 3.

Figure 3

Neonatal oxygen exposure does not alter allergen-induced AHR in adult mice. a) Timeline for allergic sensitization of adult mice exposed to room air or hyperoxia as neonates. AHR was assessed in adult animals between 54-77 days of age. b) Airway resistance and lung compliance were evaluated in adult female mice exposed to room air (Air) or 100% oxygen (O2) as neonates. Animals were not sensitized controls (Ctl), or sensitized with Alum plus saline (Alum) or Alum plus ovalbumin (OVA). All mice were challenged with OVA aerosol. Values represent the geometric mean + SE of 7-9 animals administered increasing amounts of methacholine intravenously (0.03 – 3.0 μg/kg). * p<0.05 by repeated measures ANOVA with individual contrasts showed a significant overall effect comparing Ctl versus Alum or Alum versus OVA. **p<0.05, OVA versus alum at individual methacholine doses. † p<0.05, Ctl versus Alum at individual methacholine doses.