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Percentage of methylated genes in different tissue types. Percentage of methylated genes increased from normal colons (n=24, mean=4.2%) to IBD colitis (n=25, mean=39.7%) to IBD-associated neoplasia (n=16, mean=63.4%) was seen (NC vs. IBD colitis, p< 0.01, IBD colitis vs. IBD-associated neoplasia, p=0.01). There was no significant difference between IBD neoplasia (mean=63.4%) and sporadic CRC (mean=61.3%) p=0.42.
