Table 3.
Studies showing results of utilization of nebulized corticosteroids in COPD exacerbation.
| Authors | Number of patients | Treatment given | Primary outcome | Results | Side effects |
|---|---|---|---|---|---|
| Morice et al. [6] | 19 | Nebulized budesonide – 4 mg daily Oral prednisolone – 30 mg |
To compare the FEV1 increase and biochemical parameters between the groups | Similar clinical efficacy in both groups | Urinary steroid metabolites were higher in budesonide group |
| Maltais et al. [7] | 199 | Nebulized budesonide – 8 mg daily Oral prednisolone – 60 mg Placebo |
To compare the changes in FEV1 between the groups | FEV1 improvement was similar to oral prednisolone Nebulized budesonide was associated less side effects |
Higher incidence of hyperglycemia with oral prednisolone |
| Mirici et al. [8] | 40 | Nebulized budesonide – 8 mg Daily IV prednisolone – 40 mg |
To compare the FEV1, PEF and ABG changes between the groups | Similar clinical efficacy as parenteral steroids in PEF, ABG parameters | No adverse effects |
| Gunen et al. [9] | 159 | Nebulized budesonide – 6 mg Oral prednisolone – 40 mg Standard bronchodilator therapy |
To compare the FEV1 and ABG changes between the groups | Significant improvement in FEV1 and PaO2 in budesonide group | Hyperglycemia in oral prednisolone group |
| Wei et al. [10] | 60 | Nebulized budesonide Oral prednisolone Control group |
To compare dyspnea score, FEV1 and ABG changes between the groups | Dyspnea score, FEV1 and improvement in ABG were significantly better in budesonide group | Minimal side effects |
| Gaude and Nemagouda.[11] | 125 | Nebulized budesonide – 4 mg Daily IV Hydrocortisone – 400 mg |
To compare the Spirometry variables and saturation between the groups | Spirometry variables and saturation similar in both groups | Minimal side effects |
| Our study | 86 | Nebulized budesonide – 4 mg Nebulized budesonide – 8 mg IV prednisolone – 40 mg |
To compare the PaO2 and FEV1 changes between the groups | PaO2 and FEV1 improvement similar between the groups. 8 mg seems to be first choice | Treatment failure Oral moniliazis Hyperglycemia |
FEV1 – forced expiratory volume in 1 second; ABG – arterial blood gases; PEF – peak expiratory flow; PaO2 – arterial partial pressure of oxygen.