Figure 5.

Magnetic resonance imaging scan of the damaged temporal lobe of a human that received neural stem cells labeled with magnetic nanoparticles.

Notes: The magnetic resonance images show pre- (A) and post-implantation (B) of neural stem cells into the temporal lobe. The stem cells are labeled with the magnetic nanoparticle, Feridex (Ad-Vance Magnetics Inc, Rochester, IN, USA), coupled to a transfection reagent. No signal was detected at the lesion, labeled with an asterisk, before the injection; however, 1 day post-injection, a dark area was seen around the lesion, indicating the presence of the magnetic-labeled neural stem cells. Copyright © 2011. John Wiley and Sons, Inc. Reproduced from Cromer Berman SM, Walczak P, Bulte JW. Tracking stem cells using magnetic nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3(4):343–355.³³