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. 2014 Mar 31;9:1655–1664. doi: 10.2147/IJN.S57855

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© 2014 Chung et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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SEM micrographs of (A) clot/PBS showing the RBC aggregates, platelets, and fibrin network; (B) clot/NP showing many CS NPs adhering to the surfaces of RBCs or RBC aggregates; (C) clot/ANP showing many platelet aggregates in the clot; and (D) clot/FNP showing many FNPs adhering to the RBCs or RBC aggregates.

Note: In (D), the fibrin network is also much denser than that in other clots (B and C).

Abbreviations: ANP, adenosine diphosphate–decorated chitosan nanoparticle; Clot/ANP, clot induced in ANP solution; Clot/FNP, clot induced in FNP solution; Clot/NP, clot induced in CS NP solution; Clot/PBS, clot induced in phosphate-buffered solution; CS NP, chitosan nanoparticle; FNP, fibrinogen-decorated chitosan nanoparticle; RBC, red blood cell; SEM, scanning electron microscopy.