Table 1.
Plasma steroid profile of the patient
| Basal (nmol/L) | Post-ACTH stimulation (nmol/L) | |||
|---|---|---|---|---|
|
Aldosterone |
0.166 (0.39-2.44) |
0.19 (0.01 – 0.55) |
||
|
18-OH-Corticosterone (18-OHB) |
7.06 (0.56 – 1.46) |
12.1 (0.83 – 5.5) |
||
|
Corticosterone |
44.4 (0.14 – 14.23) |
151.8 (34.0 - 208.4) |
||
|
18-OH-deoxycorticosterone |
1.64 (0.13-0.72) |
5.28 (0.58 – 6.1) |
||
|
Deoxycorticosterone |
0.57 (0.09 – 0.57) |
2.36 (0.27 – 1.35) |
||
|
Progesterone |
1.94 (0.095 – 3.15) |
2.96 (0.52 – 2.55) |
||
|
17-hydroxyprogesterone |
3.09 (0.24 – 4.93) |
15.2 (1.88 – 10.96) |
||
|
11-Deoxycortisol |
2.22 (0.15-2.58) |
14.5 (1.36 - 9.44) |
||
|
Cortisol |
274.3 (59.9 - 480) |
721.5 (317.3 – 979.3) |
||
|
Cortisone |
161.2 (6.37-123.6) |
59.9 (34.8 – 79.7) |
||
|
Ratio |
|
|
||
| B/18-OHB |
6 |
12 |
||
| 18-OHB/ aldo | 43 | 63 | ||
Plasma steroid profile showed low aldosterone level, elevated 18-hydroxycorticosterone (18-OHB), low corticosterone/18-OHB and high 18-OHB/aldosterone ratios, compatible with type 2 aldosterone synthase deficiency.