Table 1. Baseline characteristics of the study population.

Variable	Overall (n=167)	No biopsy reclassification (n=104)	Biopsy reclassification (n=63)	p-value
Age (yr)
Mean ± SD	65.7 ± 4.8	65.6 ± 4.5	65.8 ± 5.2	0.7164
Median (Range)	65.8 (50.6-76.1)	65.8 (55.0-74.9)	66.3 (50.6-76.1)
tPSA (ng/ml)
Mean ± SD	4.9 ± 3.1	4.5 ± 3.4	5.6 ± 2.3	0.0004
Median (Range)	4.6 (0.40-18.6)	3.86 (0.4-18.6)	5.31 (1.47-13.1)
Prostate volume
Mean ± SD	50.88±22.38	51.95 ± 25.31	49.07 ± 16.34	0.7663
Median (Range)	48.0 (10-145.3)	49.0 (10.0-145.3)	48.0 (21.9-90.0)
PSA density
Mean ± SD	0.10±0.06	0.09 ± 0.06	0.12 ± 0.06	<0.0001
Median (Range)	0.08 (0.02-0.39)	0.07 (0.02-0.39)	0.12 (0.04-0.32)
%fPSA
Mean ± SD	20.68 ± 7.91	22.26 ± 8.03	18.08 ± 7.03	0.0016
Median (Range)	19.45 (5.65-41.49)	21.12 (7.92-41.49)	17.52 (5.65-36.71)
%[-2]proPSA
Mean ± SD	1.54 ± 0.54	1.49 ± 0.43	1.63 ± 0.69	0.3587
Median (Range)	1.48 (0.45-4.54)	1.48 (0.52-2.64)	1.48 (0.45-4.54)
[-2]proPSA/%fPSA
Mean ± SD	0.72±0.48	0.60±0.39	0.90±0.55	0.0001
Median (Range)	0.62 (0.07-2.81)	0.52 (0.07-2.18)	0.76 (0.26-2.81)
phi
Mean ± SD	31.56±14.42	27.99±10.07	37.45±18.21	0.0002
Median (Range)	29.08 (10.55-104.62)	26.87 (10.55-64.77)	32.23 (11.14-104.62)
Number of biomarker measurements
Mean ± SD	3.32±1.54	3.47±1.51	3.11±1.57	0.067
Median (Range)	3.0 (2-10)	3.0 (2-10)	3.0 (2-8)
Time from prostate cancer diagnosis to 1st [-2]proPSA (yr)
Mean ± SD	1.27±0.95	1.39±0.92	1.07±0.97	0.001
Median (Range)	1.12 (-0.1-5.91)	1.28 (-0.04-5.91)	0.98 (-0.1-5.14)
Time from prostate cancer diagnosis to biopsy reclassification or censoring (yr)
Mean ± SD	4.43±2.10	4.81±1.93	3.81±2.23	0.0004
Median (Range)	4.30 (0.96-10.47)	4.78 (1.00-10.00)	3.41 (0.96-10.47)