Table 2.
Cox proportional hazards models and concordance indices to predict biopsy reclassification during active surveillance using (a) baseline and (b) longitudinal measurements of total PSA, %fPSA, %[-2]proPSA, [-2]proPSA/%fPSA, and phi after adjusting for age, date of diagnosis, and PSA density (n=167; 63 biopsy reclassification events).
| (a) | |||
|---|---|---|---|
| Cox Proportional Hazards Models | |||
| HR (95% CI) | P-value | C-index | |
| Baseline tPSA | 0.90 (0.80-1.00) | 0.061 | 0.630 |
| Baseline %fPSA | 0.93 (0.89-0.97) | 0.002 | 0.664 |
| Baseline %[-2]proPSA | 2.44 (1.51-3.94) | <0.0001 | 0.651 |
| Baseline [-2]proPSA/%fPSA | 2.13 (1.09-4.16) | 0.026 | 0.652 |
| Baseline phi | 1.04 (1.02-1.06) | <0.0001 | 0.662 |
| (b) | |||
|---|---|---|---|
| Cox Proportional Hazards Models | |||
| HR (95% CI) | P-value | C- index | |
| Longitudinal tPSA | 0.96 (0.88-1.05) | 0.366 | 0.703 |
| Longitudinal %fPSA | 0.94 (0.90-0.98) | 0.002 | 0.722 |
| Longitudinal %[-2]proPSA | 1.92 (1.36-2.73) | <0.0001 | 0.647 |
| Longitudinal [-2]proPSA/%fPSA | 2.12 (1.25-3.59) | 0.005 | 0.654 |
| Longitudinal phi | 1.04 (1.02-1.06) | <0.0001 | 0.635 |