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. 2014 Apr 4;9(4):e91596. doi: 10.1371/journal.pone.0091596

Figure 1. EMMPRIN-2 is overexpressed in head and neck cancer and is associated with head and neck cancer metastasis.

Figure 1

(A) EMMPRIN mRNA expression in 51 head and neck cancer tissues and the adjacent non-cancerous tissues was analyzed using qPCR. EMMPRIN-2 mRNA expression in head and neck tumor tissues is higher than that in adjacent non-cancerous tissues (p<0.01). No significant differences were observed in EMMPRIN-1 and EMMPRIN-4 mRNA expression between tumor tissues and the adjacent non-cancerous tissues (p>0.05). (B) Comparison of EMMPRIN-2 mRNA expression between 26 cases of metastatic tumors and 25 cases of tumors without any sign of local and distant metastases. EMMPRIN-2 mRNA expression was significantly increased in metastatic head and neck cancer tissues compared to non-metastatic head and neck cancer tissues (p<0.05). (C) qPCR detection of EMMPRIN mRNA expression in head and neck cancer cell lines. (D) Detection of EMMPRIN expression in head and neck cancer cell lines using Western blot. High levels of protein encoded by the EMMPRIN-2 gene were detected in all 4 of the cancer cell lines.