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. Author manuscript; available in PMC: 2014 Oct 3.
Published in final edited form as: Nature. 2014 Mar 23;508(7494):98–102. doi: 10.1038/nature13115

Figure 4. Chromothripsis alters the copy number landscape of chromosome 21 in a non-random fashion.

Figure 4

Chromosome arm-level (A) and zoomed-in view (B) of chromosome 21, showing gene expression, copy number (CN) distribution, chromothripsis effect and distribution of rearrangement breakpoints. In the gene expression panels, positive strand genes are shown in blue and negative strand genes are shown in red. C: Correlation between average rate of deletion in the Beroukhim et al.19 dataset and chromothripsis effect for chromosome 21. IQR – inter-quartile range.