Fig. 1.

N-glycosylation can regulate neural transmission by modulating voltage-gated ion channels that generate action potential on neuronal membranes, and by affecting synaptic transmission via impact on the function of synaptic vesicle proteins and postsynaptic neurotransmitter receptors. N-glycosylation is sketched as a single generic N-glycan (not to scale), while the number of modifications sites can be different for distinct proteins, and particular glycan structures can significantly vary and include some specific modifications, such as polysialylation and the HNK-1 epitopes (not shown).