Table 4. Transcripts reduced by FRLFE in rat hepatocytes.

Gene symbol	Gene description	Signal ratio (FRLFE+IL-1β/IL-1β)*	mRNA decrease by FRLFE**	asRNA	Reference
Nos2	iNOS	0.060	0.000	(+)	17
Il23a	IL-23A	0.103	0.001	(+)	29
Cx3cl1	CX3CL1	0.109	Not determined	(+)	29
Ccl20	CCL20	0.123	Not determined	(+)	29
Ccl2	CCL2	0.128	Not determined	(+)	29
Tlr2	toll-like receptor 2	0.275	Not determined	(+)	29
Tnf	TNF-α	0.281	0.005	(+)	28
Cd69	Cd69 molecule	0.284	Not determined	(+)	29
Cxcl1	CXCL1	0.321	0.005	(+)	29
Psmb10	PSMB10	0.449	Not determined	(+)	29
Ltb	lymphotoxin β	0.484	Not determined	(+)	29
Sema4a	semaphorin 4a	0.499	Not determined	(+)	29
Nfkb1	NF-κB, p50 subunit	0.660	0.041	(+)	29
Nfkbia	IκB-α	0.690	0.033	(+)	29
Rela	NF-κB, p65 subunit	0.877	0.219	(+)	29

*The fold-change in signal ratios observed by microarray analysis of the mRNA levels at 2.5 h is indicated.

**mRNA decrease represents the ratio of the mRNA levels determined by real-time RT-PCR (FRLFE + IL-1β versus IL-1β) at 4 h. The mRNA level of IL-1β was set to 100%.

(+), asRNA was experimentally detected.

iNOS, inducible nitric oxide synthase; IL-23A, interleukin 23, α subunit p19; CX3CL1, chemokine (C-X₃-C motif) ligand 1; CCL, chemokine (C-C motif) ligand; TNF-α, tumor necrosis factor α; CXCL1, chemokine (C-X-C motif) ligand 1; PSMB10, proteasome subunit, β type 10; NF-κB, nuclear factor κB; IκB-α, nuclear factor κB inhibitor α.