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. 2014 Apr 4;9(4):e93911. doi: 10.1371/journal.pone.0093911

Figure 1. Preoperative 3-day water-only fasting is neuroprotective against stroke.

Figure 1

(A) Experimental timeline indicating periods of ad libitum feeding and fasting relative to the onset of tMCAO on day 0. AL, ad libitum fed (n = 11); FA, fasted (n = 14). (B) Average body weights prior to and after tMCAO; F8, 23 = 17.69, ***p<0.0001, 2-way ANOVA. (C) Blood glucose levels on the indicated days prior to and after tMCAO; F2, 23 = 14.09, ***p<0.0001, 2-way ANOVA. (D) Body temperature before tMCAO and 1 hour after reperfusion; ***/###p<0.001, Student's t-test. (E) Infarction volumes at d7 after tMCAO; *p = 0.0215, Student's t-test. (F) Representative MRI images of the lesioned brain sections with green lines surrounding the lesion.