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A model of MeCP2-e1 function in neurons. In this model, non-pS30 MeCP2-e1 forms a molecular complex with RNA regulatory factors on the nuclear matrix in the neuronal nucleoplasm. Neuronal signals trigger phosphorylation of MeCP2 at phosphoserine 30 leading to dissociation from the nuclear matrix and relocalization of MeCP2 to heterochromatin in chromocenters.
