Table 2. Meta-analysis of the associations between TLR-4 genetic polymorphisms and colorectal cancer risk.

	M allele vs. W allele			WM + MM vs. WW			MM vs. WW + WM			MM vs. WW			MM vs. WM
	(Allele model)			(Dominant model)			(Recessive model)			(Homozygous model)			(Heterozygous model)
	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P
Overall	1.42	1.17∼1.72	<0.001	1.41	1.14∼1.74	0.002	1.85	1.00∼3.44	0.051	1.93	1.04∼3.59	0.038	1.61	0.82∼3.13	0.163
SNP type
299 A>G	1.21	0.94∼1.56	0.149	1.15	0.87∼1.52	0.323	1.65	0.77∼3.54	0.198	1.67	0.78∼3.59	0.187	1.61	0.70∼3.69	0.257
399 C>T	1.77	1.32∼2.36	<0.001	1.83	1.32∼2.52	<0.001	2.32	0.80∼6.72	0.120	2.54	0.88∼7.38	0.086	1.60	0.52∼4.93	0.417
Ethnicity
Africa	1.49	0.84∼2.62	0.173	1.44	0.77∼2.72	0.256	3.63	0.17∼76.40	0.407	3.63	0.17∼76.57	0.407	3.65	0.16∼82.33	0.416
Asians	1.50	1.19∼1.88	0.001	1.49	1.19∼1.92	0.002	2.01	0.96∼4.21	0.065	2.11	1.01∼4.44	0.048	1.68	0.76∼3.72	0.202
Caucasians	1.13	0.72∼1.78	0.539	1.10	0.66∼1.81	0.719	1.33	0.37∼4.82	0.664	1.36	0.40∼4.61	0.625	1.14	0.17∼7.46	0.895
Genotyping method
Non-PCR-RFLP	1.37	0.88∼2.12	0.166	1.26	0.78∼2.04	0.351	2.15	0.60∼7.69	0.238	2.21	0.62∼7.90	0.223	1.85	0.46∼7.38	0.382
PCR-RFLP	1.44	1.16∼1.78	0.001	1.44	1.14∼1.82	0.002	1.77	0.87∼3.60	0.115	1.85	0.91∼3.76	0.090	1.54	0.72∼3.30	0.267
Sample size
Large (n > 200)	1.48	1.19∼1.86	0.001	1.43	1.10∼1.87	0.008	3.02	1.24∼7.38	0.015	3.17	1.30∼7.76	0.011	2.60	1.03∼6.54	0.043
Small (n ≤ 200)	1.26	0.87∼1.83	0.217	1.29	0.84∼1.97	0.246	1.18	0.50∼2.78	0.709	1.21	0.51∼2.87	0.660	0.95	0.36∼2.50	0.916

Legend: W - wild allele; M - mutant allele; WW - wild homozygote; WM - heterozygote; MM - mutant homozygote; OR - odds ratio; 95%CI - 95% confidence interval; SNP - single nucleotide polymorphism; PCR-RFLP - polymerase chain reaction-restriction fragment length polymorphism.