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. 2014 Apr 4;9(4):e93604. doi: 10.1371/journal.pone.0093604

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© 2014 McGillivray et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The heat map show results of unsupervised hierarchical clustering focusing on the genes with the highest magnitude of change. A majority of genes induced by diamide treatment in Mtb are also induced in Mtb:ΔRv2745c (comp) by 60 minutes and not induced in Mtb:ΔRv2745c. Genes that are induced in Mtb are also induced in Mtb:ΔRv2745c (comp), whereas there is no change in expression levels in the isogenic mutant indicating that Rv2745c plays a the redox response. n = 3. Red color indicates induction while blue color indicates repression, relative to the control channel. The intensity of each color corresponds to the magnitude.