. 2014 Apr 4;9(4):e93938. doi: 10.1371/journal.pone.0093938

Table 2. Stratification analyses of combined effects of TGFB1 +869 T/C and +915 G/C polymorphisms on acute rejection risk.

Category	LP vs. HP				IP vs. HP				LP/IP vs. HP
	N^a	OR(95% CI)	P^b	P^c	N^a	OR(95% CI)	P^b	P^c	N^a	OR(95% CI)	P^b	P^c
Total	11	1.10(0.71,1.71)	0.665	0.373	14	0.75(0.58,0.96) ^d	0.021 ^d	0.238	14	0.77(0.61,0.98) ^d	0.030 ^d	0.144
Ethnicity
Asian	1	1.14(0.05,29.0)	0.938	—	3	0.76(0.36,1.60)	0.466	0.242	3	0.74(0.35,1.55)	0.425	0.303
Caucasian	6	0.93(0.54,1.61)	0.807	0.165	7	0.80(0.58,1.10)	0.174	0.251	7	0.78(0.58,1.06)	0.112	0.094
Mixed	4	1.58(0.72,3.49)	0.258	0.507	4	0.65(0.42,1.03)	0.064	0.163	4	0.77(0.51,1.16)	0.214	0.160
Transplantation Types
RTx	7	1.23(0.75,2.01)	0.406	0.401	9	0.88(0.66,1.17)	0.377	0.290	9	0.91(0.69,1.19)	0.473	0.154
LTx	2	0.33(0.07,1.69)	0.185	0.996	3	0.64(0.35,1.16)	0.142	0.737	3	0.59(0.33,1.06)	0.076	0.774
HTx	2	1.50(0.34,6.57)	0.594	0.180	2	0.32(0.14,0.73) ^d	0.006 ^d	0.790	2	0.41(0.20,0.85) ^d	0.017 ^d	0.320
Immunosuppressive protocol
CsA	3	1.37(0.41,4.59)	0.607	0.462	5	0.57(0.34,0.94) ^d	0.027 ^d	0.491	5	0.62(0.38,1.01)	0.055	0.694
CsA/FK506	8	1.07(0.66,1.71)	0.793	0.229	9	0.82(0.62,1.09)	0.169	0.194	9	0.83(0.64,1.08)	0.162	0.059

Abbreviations: RTx, renal transplantation; LTx, liver transplantation; HTx, heart transplantation; CsA, cyclosporine A; FK506, tacrolimus; LP, low producer; IP, intermediate producer; HP, high producer.

—, cannot be calculated;

Number of eligible studies;

P value of Z-test for significance of OR;

P value of Q-test for heterogeneity test;

Statistically significant results (in bold).