Figure 7. Knockdown of matriptase expression increases susceptibility to CdCl₂ toxicity.

(A) Evaluation of matriptase and HAI-1 expression in matriptase knockdown (KD) and non-target (NT) control cells using immunoblot analyses of cell lysates to detect total matriptase (MTP) or HAI-1 (HAI-1). (B) Survival rates of matriptase knockdown cells (open circles) in comparison to non-target (NT) control cells (closed circles). Each cell pool was exposed to various concentrations of CdCl₂, and survival ratios determined by crystal violet staining assay. The results from one representative experiment out of four replicates are shown.