Table 2.
Comparison of demographic and clinical characteristics and laboratory findings on admission day among children with different concentrations of blood lactate
| Admission blood lactate, mmom/l | 0.0-2.0 | 2.1-4.0 | 4.1-6.0 | 6.1-8.0 | 8.1-10.0 | >10.0 | P value |
|---|---|---|---|---|---|---|---|
| n |
250 |
485 |
204 |
79 |
34 |
57 |
|
| Age, years |
1.75 [0.58-4.00] |
1.00 [0.33-3.00] |
0.67 [0.25-2.00] |
0.54 [0.25-3.50] |
0.42 [0.17-1.25] |
0.92 [0.33-3.00] |
<0.001 |
| Gender, male/female |
163/87 |
304/181 |
122/82 |
60/19 |
9/25 |
31/26 |
<0.001 |
| PRISM III score |
3 [0–6] |
3 [0–6] |
3 [0.75-7] |
5 [2–11] |
8 [4–15.75] |
14 [6–24] |
<0.001 |
| MODS ≥3a, n |
11 (4.4) |
24 (4.9) |
20 (9.8) |
20 (25.3) |
12 (35.3) |
34 (59.6) |
<0.001 |
| Mechanical ventilationb, n |
29 (11.6) |
95 (19.6) |
48 (23.5) |
23 (29.1) |
13 (38.2) |
31 (54.4) |
<0.001 |
| In-hospital mortality, n |
7 (2.8) |
27 (5.6) |
18 (8.8) |
14 (17.7) |
9 (26.5) |
40 (70.2) |
<0.001 |
| Laboratory findings on admission dayc | |||||||
| Albumin, g/l |
42.6 |
42.7 |
42.0 |
40.2 |
39.6 |
32.8 |
<0.001 |
| [39.1-45.8] |
[39.8-46.0] |
[39.9-45.7] |
[34.2-44.5] |
[35.9-43.15] |
[29.0-40.0] |
||
| Glucose, mmol/l |
6.50 |
6.90 |
7.60 |
8.90 |
11.35 |
16.27 |
<0.001 |
| [5.35-8.00] |
[5.70-9.00] |
[6.15-11.37] |
[6.65-14.02] |
[7.40-21.21] |
[10.78-27.90] |
||
| Creatinine, μmol/l |
28.2 |
27.4 |
27.8 |
31.7 |
37.6 |
62.4 |
<0.001 |
| [23.2-35.5] |
[23.2-35.0] |
[23.1-37.5] |
[22.8-48.8] |
[25.9-60.1] |
[43.0-79.7] |
||
| BUN, μmol/l |
3.64 |
3.70 |
3.59 |
4.46 |
4.87 |
4.72 |
<0.001 |
| [2.62-5.04] |
[2.62-4.92] |
[2.35-5.12] |
[2.85-6.69] |
[3.04-6.48] |
[3.80-6.92] |
||
| Total bilirubin, μmol/l |
6.08 |
6.50 |
7.01 |
9.43 |
4.91 |
6.71 |
<0.001 |
| [4.20-8.50] |
[4.21-9.73] |
[4.73-11.69] |
[6.18-17.28] |
[3.33-8.89] |
[4.03-12.61] |
||
| Bicarbonate, μmol/l |
21.4 |
20.8 |
20.8 |
17.7 |
15.9 |
11.5 |
<0.001 |
| [18.8-24.4] |
[18.4-24.0] |
[17.9-23.8] |
[14.8-21.4] |
[11.7-20.4] |
[6.6-15.3] |
||
| Arterial pH | 7.439 |
7.421 |
7.390 |
7.368 |
7.267 |
7.177 |
<0.001 |
| [7.385-7.488] | [7.364-7.476] | [7.332-7.456] | [7.304-7.464] | [7.141-7.338] | [7.005-7.272] | ||
Values are median [interquartile range]. Numbers in parentheses denote percentages.
BUN, blood urea nitrogen; MODS, multi-organ dysfunction syndrome; PRISM III, pediatric risk of mortality III.
aMODS developed during hospitalization. bAdministration during hospitalization. cThe first available laboratory values during the first 24 hours after admission.