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Detection of the AMPK/mTOR signaling pathway after combination treatment with metformin and tamoxifen in MCF-7 and ZR-75-1 cells. (A-B) MCF-7 and ZR-75-1 cells were treated with 5 mM Met for different times (0, 6, 12, 18, 24 and 48 hours). (C-D) MCF-7 and ZR-75-1 cells were treated with 5 mM Met, 10 μM Tam or 10 μM Tam + 5 mM Met for 2 days. Protein was extracted and subjected to western blot. The expression of the target proteins was normalized to β-actin.
