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. 2014 Apr 4;9(4):e94178. doi: 10.1371/journal.pone.0094178

Figure 8. The multi-steps of mechanism of CXCL-8 binding to receptor CXCR1 in membranes.

Figure 8

Step1: The N-loop residues of CXCL-8 bind to the N-terminus of receptor CXCR1 leading to Site-I binding. The Site-I binding is dominated mainly by the electrostatic interactions. Step2: Hydrophobic interactions near the binding site dominate to trigger the CXCL-8 rotation and conformational change. Step3: The rotation and conformational change of CXCL-8 may carry on and electrostatic interactions again dominate to attract the N-terminal ELR motif of CXCL-8 to approach the EC-loops of CXCR1 leading to Site-II binding.