Table 1. Anthropometrics, laboratory and insulin metabolism related parameters of controls and PCOS patients according to the obesity status.
| Normal weight women | Overweight women | Obese women | |||||||
| Controls | PCOS | P | Controls | PCOS | p | Controls | PCOS | p | |
| N | 271 | 29 | 151 | 24 | 57 | 16 | |||
| Age (years) | 25.8±3.4 | 25.2±4.7 | 0.09 | 25.5±3.52 | 25.1±6.21 | 0.2 | 25.3±5.13 | 28.75±8.5 | 0.1 |
| BMI (kg/m2) | 21.5±1.8 | 21.1±1.8 | 0.3 | 26.5±1.7 | 26.6±1.7 | 0.8 | 34.3±4.3 | 37.4±6.6 | 0.06 |
| Waist circumference (cm) | 70.6±6.7 | 73.1±6.9 | 0.2 | 85.2±8.6 | 90.4±9.6 | 0.08 | 97.6±8.6 | 107.5±12.4 | 0.01 |
| Total cholesterol (mmol/l) | 4.23±0.6 | 4.53±0.8 | 0.03 | 4.44±0.8 | 4.61±0.8 | 0.3 | 4.66±0.83 | 4.82±0.93 | 0.6 |
| HDL-cholesterol (mmol/l) | 1.67±0.37 | 1.64±0.28 | 0.7 | 1.47±0.33 | 1.44±0.39 | 0.9 | 1.36±0.34 | 1.24±0.21 | 0.3 |
| LDL-cholesterol (mmol/l) | 2.32±0.63 | 2.5±0.72 | 0.2 | 2.72±0.76 | 2.53±0.82 | 0.3 | 2.89±0.86 | 3.09±0.86 | 0.2 |
| Triglycerides (mmol/l) | 0.62±0.35 | 0.78±0.34 | <0.0001 | 0.93±0.47 | 1.03±0.73 | 0.9 | 1.03±0.45 | 1.22±0.63 | 0.3 |
| Fasting glucose (mmol/l) | 4.73±0.51 | 4.8±0.36 | 0.7 | 4.94±0.48 | 4.91±0.47 | 0.7 | 4.90±0.45 | 5.13±0.59 | 0.4 |
| Fasting Insulin (μUI/ml) | 4.38±2.23 | 9.41±4.08 | <0.0001 | 6.59±6.58 | 11.13±3.67 | <0.0001 | 12.26±8.25 | 20.63±9.61 | <0.0001 |
| 2 hour glucose (mmol/l) | 5.11±0.96 | 5.22±1.15 | 0.6 | 5.37±1.05 | 5.36±1.17 | 0.9 | 5.79±1.21 | 5.84±1.14 | 0.9 |
| HOMA-IR | 0.91±0.49 | 2.01±0.89 | <0.0001 | 1.36±0.65 | 2.43±0.86 | <0.0001 | 2.19±1.09 | 4.77±2.62 | <0.0001 |
| WBISI | 12.8±5.9 | 6.8±2.95 | <0.0001 | 9.09±4.16 | 5.31±1.80 | <0.0001 | 5.73±3.24 | 3.14±1.76 | <0.0001 |
| Fasting insulin secretion (pmol min−1m−2) | 61.55±22.2 | 82.1±26.8 | <0.0001 | 74.29±25.7 | 94.92±28.0 | 0.001 | 114.9±37.7 | 157.8±51.2 | <0.0001 |
| Total insulin secretion (nmol m−2) | 37.9±12.1 | 60±23.6 | <0.0001 | 39.1±11.8 | 53.95±14 | <0.0001 | 52±16.5 | 69.8±21.6 | <0.0001 |
| AUC insulin (μUI/ml min−1) | 50.6±36.9 | 197±109.1 | <0.0001 | 54.9±22.3 | 240.5±116.9 | <0.0001 | 96.15±62.3 | 381±227.6 | <0.0001 |
| Total Insulin Secretion@5WBISI (nmol m−2) | 0.80±0.72 | 2.48±2.45 | <0.0001 | 1.14±0.85 | 2.36±1.16 | <0.0001 | 2.44±1.68 | 6.08±4.04 | <0.0001 |
| ISSI-2 | 2.71±1.1 | 2.37±1 | 0.4 | 2.36±1.03 | 2.14±0.70 | 0.3 | 1.98±0.79 | 1.82±0.63 | 0.7 |
Data are expressed as mean ± SD. P refers to statistical significance at the Mann-Whitney U test within groups of normal-weight, overweight and obese women. BMI, body Mass Index; HDL, High density lipoprotein; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; LDL, Low density lipoprotein; WBISI, Whole Body Insulin Sensitivity Index; ISSI-2, Insulin Secretion-Sensitivity Index-2; Total Insulin, Total insulin secretion at a WBISI of 5.