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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):623–630. doi: 10.1097/MPG.0b013e318286891e

FIGURE 1.

FIGURE 1

Glucagon-like peptide-2 (GLP-2) delays the onset but does not prevent necrotizing enterocolitis (NEC). Piglets delivered 12 days preterm were randomized to control (CON) or GLP-2 treatment and given TPN for 2 days. On day 3, TPN was withdrawn and enteral feeds were initiated. Animals were then monitored for clinical signs of NEC. A, GLP-2–infused animals had a significantly longer average survival time after the initiation of enteral feeds compared with CON. B, Kaplan-Meier analysis of both groups showed that although GLP-2 delayed the onset of NEC, mortality was not different between the groups. C, Clinical score, consisting of the presence or absence of abdominal distention, diarrhea, and vomiting, as well as the macroscopic appearance of damage in all segments of the gut. The GLP-2–infused animals tended to have a lower clinical score compared with control piglets. D, The overall incidence of NEC was not different between CON and GLP-2.