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Glucagon-like peptide-2 (GLP-2) increased villous height (A) and area (B). Piglets delivered 12 days preterm were randomized to control or GLP-2 treatment and given total parenteral nutrition (TPN) for 2 days. On day 3, total parenteral nutrition (TPN) was withdrawn and enteral feeds were initiated for 96 hours. Upon euthanasia, intestine was collected for histology. GLP-2 stimulated increased villous height and area in both the proximal jejunum and distal ileum. Scale bar = 200 μm/L.
