Table 2.
BE | Colonoscopy controls
|
Endoscopy controls
|
|||||
---|---|---|---|---|---|---|---|
n | n | Unadjusted OR (95 % CI) | Adjusted ORa (95 % CI) | n | Unadjusted OR (95 % CI) | Adjusted ORa (95 % CI) | |
Smoking status | |||||||
Never smokerb | 60 | 113 | 1.00 (ref) | 1.00 (ref) | 318 | 1.00 (ref) | 1.00 (ref) |
Ever smoker | 198 | 340 | 1.10 (0.77–1.57) | 0.84 (0.53–1.32) | 827 | 1.27 (0.93–1.74) | 1.09 (0.78–1.52) |
Ex-smoker | 110 | 205 | 1.01 (0.69–1.49) | 0.74 (0.45–1.22) | 438 | 1.33 (0.94–1.88) | 1.06 (0.73–1.53) |
Current smoker | 88 | 135 | 1.23 (0.81–1.85) | 0.99 (0.59–1.68) | 389 | 1.20 (0.84–1.72) | 1.12 (0.77–1.64) |
Smoking intensity (cigarettes/day) | |||||||
≤15 | 61 | 158 | 0.73 (0.47–1.12) | 0.64 (0.38–1.11) | 307 | 1.05 (0.71–1.55) | 1.17 (0.77–1.76) |
15.01–20 | 65 | 101 | 1.21 (0.78–1.89) | 1.04 (0.60–1.81) | 276 | 1.25 (0.85–1.84) | 1.02 (0.68–1.52) |
> 20 | 71 | 81 | 1.65 (1.06–2.58) | 0.91 (0.52–1.59) | 243 | 1.55 (1.06–2.27) | 1.08 (0.72–1.62) |
p-trendc | < 0.001 | 0.27 | 0.05 | 0.80 | |||
Age at smoking initiation (years) | |||||||
≤15 | 67 | 104 | 1.21 (0.78–1.88) | 0.76 (0.44–1.32) | 275 | 1.29 (0.88–1.90) | 1.03 (0.69–1.54) |
16–18 | 81 | 125 | 1.22 (0.80–1.86) | 1.01 (0.60–1.71) | 308 | 1.39 (0.96–2.02) | 1.14 (0.78–1.68) |
> 18 | 49 | 111 | 0.83 (0.53–1.32) | 0.71 (0.40–1.27) | 244 | 1.06 (0.70–1.61) | 1.07 (0.69–1.65) |
p-trendc | 0.11 | 0.85 | 0.39 | 0.75 | |||
Smoking duration (years) | |||||||
≤25 | 70 | 121 | 1.09 (0.71–1.67) | 0.79 (0.46–1.36) | 255 | 1.46 (0.99–2.13) | 1.21 (0.81–1.81) |
25.01–40 | 67 | 134 | 0.94 (0.61–1.45) | 0.72 (0.41–1.26) | 320 | 1.11 (0.76–1.63) | 1.04 (0.70–1.56) |
> 40 | 61 | 85 | 1.35 (0.86–2.13) | 1.05 (0.60–1.84) | 252 | 1.28 (0.87–1.90) | 1.01 (0.66–1.53) |
p-trendc | 0.52 | 0.49 | 0.40 | 0.43 | |||
Pack-years of smoking | |||||||
≤15 | 50 | 122 | 0.77 (0.49–1.22) | 0.66 (0.37–1.17) | 240 | 1.10 (0.73–1.67) | 1.05 (0.68–1.61) |
15.01–40 | 74 | 130 | 1.07 (0.70–1.64) | 0.94 (0.55–1.60) | 320 | 1.23 (0.84–1.78) | 1.16 (0.79–1.72) |
> 40 | 73 | 88 | 1.56 (1.01–2.43) | 0.91 (0.53–1.59) | 266 | 1.46 (1.00–2.12) | 1.03 (0.69–1.54) |
p-trendc | 0.002 | 0.34 | 0.17 | 0.96 | |||
Smoking cessation (years) | |||||||
≤15 | 42 | 76 | 1.04 (0.64–1.70) | 0.73 (0.39–1.37) | 176 | 1.27 (0.82–1.95) | 1.12 (0.71–1.77) |
15.01–30 | 37 | 70 | 1.00 (0.60–1.65) | 0.86 (0.46–1.62) | 171 | 1.15 (0.73–1.80) | 0.86 (0.53–1.39) |
> 30 | 31 | 59 | 0.99 (0.58–1.69) | 0.57 (0.29–1.13) | 91 | 1.81 (1.10–2.95) | 1.23 (0.72–2.09) |
p-trendc | 0.86 | 0.56 | 0.25 | 0.66 |
BE Barrett’s esophagus, CI confidence interval, OR odds ratio
Adjusted for age, sex, race, duration of GERD symptoms, WHR, H. pylori infection, PPI use and NSAID use
Reference group for all analyses is never smokers
p for trend excludes never smokers