Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Gene Ther. 2014 Feb 27;21(4):379–386. doi: 10.1038/gt.2014.7

Figure 5. Bortezomib Enhances AAV9 Transduction in HeLa Cells and Neonatal Rat Cardiomyocytes but Decreases Transduction in Adult Rat Cardiomyocytes.

Figure 5

A: HeLa cells were pre-treated for 30 minutes with DMSO or bortezomib (1.25 μM) and infected with AAV2-Luciferase or AAV9-Luciferase (1e4 vg/cell). After 24h cells were lysed and firefly luciferase activity was measured. B: Neonatal Rat Cardiomyocytes were infected with AAV2-Luciferase, AAV6-Luciferase or AAV9-Luciferase (1e4 vg/cell) in the presence of DMSO or bortezomib (1 μM). Luciferase activity was measured 24h post-infection, C: Adult Rat Cardiomyocytes were infected with AAV2-Luciferase, AAV6-Luciferase or AAV9-Luciferase (1e4 vg/cell) in the presence of DMSO or bortezomib (1 μM). Luciferase activity was measured 48h post-infection. * = p<0.05.