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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2013 Oct 4;144PA:132–137. doi: 10.1016/j.jsbmb.2013.09.012

Figure 1. Megalin and the receptor-mediated uptake of 25-hydroxyvitamin D in the kidney.

Figure 1

DBP-bound 25OHD in the glomerular filtrate is recovered via expression of the multi-ligand membrane receptor megalin which endocytically internalizes DBP in proximal tubule epithelial cells. The resulting release of 25OHD provides substrate for the mitochondrial 1α-hydroxylase and leads to renal synthesis of 1,25(OH)2D to facilitate circulating levels of this hormone and support endocrine actions of this hormone, whilst also maintaining circulating levels of 25OHD.