Table 5.
Benign disease-associated HLH | Range | LAHS | Range | p value | |
---|---|---|---|---|---|
Mean ± SD | Mean ± SD | ||||
n = 10 | n = 11 | ||||
WBC (×109/l) | 4,050 ± 1,152 | 600–13,800 | 4,509 ± 799 | 1,800–10,700 | NS |
ANC (×109/l) | 2,440 ± 1,170 | 189–12,765 | 3,119 ± 650 | 1,026–7,875 | <0.05 |
Hb (g/dl) | 11.8 ± 0.5 | 9.2–13.8 | 9.4 ± 0.5 | 7.4–12.6 | <0.01 |
PLT (×109/l) | 7.2 ± 1.1 | 4.2–13.9 | 10.8 ± 1.4 | 5.0–20.5 | <0.05 |
AST (U/l) | 1,161 ± 622 | 40–6,300 | 63.4 ± 14.2 | 20–157 | <0.01 |
ALT (U/l) | 904 ± 391 | 37–3,400 | 36.3 ± 10.9 | 8–132 | <0.001 |
LDH (/UNL) | 8.1 ± 3.2 | 1.4–32.3 | 3.6 ± 0.7 | 1.3–8.9 | NS |
CRP (mg/dl) | 9.4 ± 2.9 | 0.4–23.6 | 9.0 ± 2.6 | 0.3–29.3 | NS |
sIL-2R (U/ml) | 4,176 ± 677 | 2,162–8,657 | 13,451 ± 3,611 | 3,462–36,938 | <0.005 |
Ferritin (ng/ml) | 20,462 ± 9,330 | 882–100,000 | 2,561 ± 544 | 619–6,067 | <0.005 |
sIL-2R/ferritin | 0.66 ± 0.25 | 0.06–2.73 | 8.56 ± 2.79 | 0.72–31.1 | <0.0005 |
UNL upper normal limit, NS not significant