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The in situ hybridization technique employed specific molecular probes directed to protein Z mRNA (a) and protein Z-dependent protease inhibitor mRNA (b). Dark brown staining (solid arrows) for the proteins in tumor cells of gastric cancer indicating constitutive synthesis of the proteins in these cells. No staining for PZ mRNA (c) or ZPI mRNA (d) was observed in normal gastric tissue. Hematoxylin counterstain, original magnification ×200 (a, c, d) and x400 (b)
