TABLE 1.

Systemic characteristics of normal, hypertensive, hypertensive + revascularization, and hypertensive + revascularization + Bendavia pigs (n=7 each) 4 weeks after percutaneous transluminal renal angioplasty or sham

	Normal	Hypertensive	Hypertensive + revascularization	Hypertensive + revascularization +Bendavia
Number of animals	7	7	7	7
Body weight (kg)	45.5 ±2.3	43.8 ±1.9	42.6 ±1.5	47.7 ±2.4
Degree of stenosis (%)	0	87.5 ±7.5^*,^‡	0	0
Mean arterial pressure (mmHg)	87.2 ±4.6	150.9 ±7.6^*	90.5 ±6.8	91.5 ±8.5
Total cholesterol (mg/dl)	92.2 ±17.9	498.9 ±61.3^*	504.3 ±190.2^*	469.8 ±97.0^*
Low-density lipoprotein (mg/dl)	47.8 ±9.5	314.8 ±78.4^*	253.7 ±86.4^*	247.8 ± 142.4^*
8-Epi-isoprostane (pg/ml)	83.2 ±6.7	134.9 ±9.8^*,^‡	142.2 ±14.0^*,^‡	120.2 ±15.8
Stenotic-kidney GFR (ml/min)	82.8 ±10.4	50.0 ±4.2^*	45.4 ±2.8^*,^‡	69.4 ±4.8
Heart rate (bpm)	71.7 ±9.5	78.4 ±9.1	78.1 ±6.4	74.1 ±9.1
Rate–pressure product (mmHg × bpm)	177.1 ±29.5	356.6 ±53.3^*,^‡	196.0 ±17.7^‡	159.2 ±25.6
Stroke volume	44.0 ±7.4	41.6 ±7.6	42.4 ±3.0	44.2 ±6.3
Cardiac output (l/min)	3.1 ±0.6	3.5 ±1.1	3.2 ±0.2	3.4 ±0.7
E/A ratio	1.3 ±0.2	0.7 ±0.2^*,^‡	0.9 ±0.2^*,^‡	1.2 ±0.3
LVMM (g/kg body weight)	0.8 ±0.1	1.3 ±0.2^*,^‡	0.9 ±0.1	0.9 ±0.2
Myocardial perfusion (ml/min g⁻¹)	0.8 ±0.3	0.7 ±0.1	0.8 ±0.1	0.8 ±0.1

E/A, early (E) and atrial (A) ventricular filling; GFR, glomerular filtration rate; LVMM, left ventricular muscle mass.

P ≤0.05 vs. normal;

^‡

P <0.05 vs. RVHT +PTRS +Bendavia.