FIG. 1.

KH-type splicing regulatory protein (KSRP) negatively regulates cytokine and chemokine mRNA expression at multiple levels. KSRP promotes mRNA decay by binding to AU-rich elements in the 3′ untranslated region (UTR) and associating with the exosome (RNA degradation machine), and by binding to microRNA precursors and promoting their maturation. KSRP silences translation through dissociation of the mRNA from the polysome. KSRP also represses cytokine transcription by mechanisms that are not yet understood.