Table 1.

Cytokine/Chemokine mRNAs Regulated by KSRP

mRNA target	mRNA degradation	Translational silencinga	miRNA-mediated	Cell type	Reference(s)
Chemokines
CXCL2	x			T98G, HeLa	Herjan and others (2013)
CXCL3	x			T98G, HeLa	Graham and others (2010) and Herjan and others (2013)
CXCL8	x			HeLa	Winzen and others (2007)
CXCL10		x		HeLa	Dhamija and others (2011)
			miR-155	Macrophage	Ruggiero and others (2009)
CXCL11			miR-155	Macrophage	Ruggiero and others (2009)
CCL2	x			T98G	Graham and others (2010)
			miR-155	Macrophage	Ruggiero and others (2009)
CCL5			miR-155	Macrophage	Ruggiero and others (2009)
CCL20		x		HeLa	Dhamija and others (2011)
Cytokines
CSF2	x			HeLa	Winzen and others (2007)
IFNB1		x		HeLa	Dhamija and others (2011)
IL-1α		x		HeLa	Dhamija and others (2011)
IL-1β	x	?		Astrocytes	Li and others (2012)
				RAW264.7
			miR-155	Macrophage	Ruggiero and others (2009)
IL-6	x	x		HeLa	Dhamija and others (2011) and Winzen and others (2007)
IL-10			miR-155	Macrophage	Dhamija and others (2011) and Winzen and others (2007)
IL-12			miR-155	Macrophage	Dhamija and others (2011)
IL-23A		x		HeLa	Dhamija and others (2011)
TNF-α	x	x		Astrocytes	Li and others (2012), Dhamija and others (2011) and Winzen and others (2007)
				RAW264.7 HeLa
TNF-α	Transcriptional repression			Astrocytes	Li and others (2012)
				RAW264.7
Related
ATF3		x		HeLa	Dhamija and others (2011)
IRF1		x		HeLa	Dhamija and others (2011)
IL-16R		x		HeLa	Dhamija and others (2011)
INOS	x			DLD-1	Linker and others (2005), Schmidt and others (2010), and Zhou and others (2012)
				Chondrocytes
				Gut epithelial cells
SOCS3			miR-155	Macrophage	Ruggiero and others (2009)
TREM-1	Transcriptional repression			Astrocytes	Li and others (2012)

^aAs defined by polysome redistribution with KSRP knockdown.

KSRP, KH-type splicing regulatory protein.