Table 1.
Post-translational modification of Drp1 by phosphorylation
| Reference | Cell-type | Regulator | Drp1 phosphorylation site | Effect |
|---|---|---|---|---|
| Taguchi et al., 2007 | HeLa | Cyclin-dependent kinase (Cdk1) | Ser585 with no effect of GTPase activity (Ser585 is the rat Drp1 splice variant 1 of Ser616) | Cdk1 phosphorylates Drp1 and activates it during cell division |
| Chang and Blackstone, 2007 | HeLa | PKA | Ser637 in the GTPase effector domain | PKA phosphorylates Drp1 and inhibits GTPase activity |
| Cribbs and Strack, 2007 | PC12 | PKA Calcineurin Calcium | Ser656 with no effect of GTPase activity (Ser656 is the rat Drp1 splice variant 1 of Ser637) | PKA phosphorylates Drp1 and inhibits GTPase activity preventing apoptosis Calcineurin and calcium dephosphorylates Drp1 and activates it enhancing apoptosis |
| Cereghetti et al., 2008 | Calcineurin Calcium | Ser637 | Calcineurin and calcium dephosphorylates Drp1 and activates it enhancing apoptosis | |
| Han et al., 2008 | HeLa neurones | Ca2+/calmodulin-dependent PKI 1 (CaMKIα) | Ser600 (Ser600 is the Drp1 splice variant of Ser637) | CaMKIα phosphorylates Drp1 and activates it |
| Marsboom et al., 2012 | Pulmonary arterial smooth muscle cells | Cdk1 | Ser616 | Cdk1 phosphorylates Drp1 and activates it during cell division |
| Din et al., 2013 | Neonatal cardiomyocytes | Pim-1 | Ser637 | Pim-1 phosphorylates Drp1 and inhibits fission |